By bringing together radiobiologists across Europe, RADIATE intends to develop new therapeutic strategies to improve the outcome of radiation therapy.
The failure to eliminate the cancer at its primary site can be placed into two general categories
The intrinsic ability of the tumour to repair the radiation damage.
The interplay between the tumour microenvironment and the cancer cells leading to greater resistance. The tumour microenvironment can affect hypoxia and the host’s immune response to the tumour, both factors known to strongly influence tumour response to radiation.
Exploration of these two categories form our first two scientific aims (Work Package 1 and 2) with translational work designed to identify and implement new therapeutic strategies for use in radiotherapy being the third (Work Package 3).